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  • Writer's pictureVassilios Della Cioppa

Harnessing Neuroplasticity: Novel Approaches to Healing the Human Brain

By Vassilios Della Cioppa | Published 6/22/2023

Ice cubes, Coconut, Mushroom, Brain
Ice Cubes, a Coconut, and a Mushroom - By Vassilios Della Cioppa

Highlights

  • MCT oil enhances cognition.

  • Psilocybin promotes neural plasticity.

  • Cold exposure improves brain function.

Introduction

With its intricate network of billions of neurons, the human brain possesses a remarkable ability to adapt and repair itself through neuroplasticity. Neuroplasticity refers to the brain's capacity to reorganize and form new connections between neurons, allowing for learning, memory, and recovery from injuries or neurological conditions. Researchers have made significant strides in understanding how various interventions can harness this neuroplasticity to promote brain healing and enhance cognitive functions. In this article, we delve into three innovative approaches: using MCT oil as high-octane fuel for the brain, the potential of psilocybin in regrowing dendritic spines, and the transformative effects of cold exposure on brain function and overall well-being.


MCT Oil

Medium-chain triglyceride (MCT) oil, derived from coconut or palm kernel oil, has garnered attention for its potential cognitive benefits. MCTs are unique fatty acids that are rapidly absorbed and metabolized by the liver, producing ketones as a byproduct. Ketones serve as an alternative fuel source for the brain when glucose availability is limited, such as during periods of fasting or a low-carbohydrate diet.


Several studies have shown that the ketones produced from MCT oil metabolism can enhance cognitive performance. According to Dr. Mary Newport, a leading Alzheimer's researcher, "this fatty acid can directly cause ketones to be produced in astrocytes." The brain readily absorbs and utilizes ketones, which serve as a more efficient energy source than glucose, especially in conditions such as neurodegenerative disorders or traumatic brain injuries.


In a study published in Neurobiology of Aging, researchers found that MCT oil supplementation improved cognitive function in individuals with mild cognitive impairment, a condition often considered a precursor to Alzheimer's disease. The study participants who consumed MCT oil demonstrated better memory performance and increased levels of ketones in the brain compared to the control group.


Psilocybin

Psilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, has been gaining attention for its potential therapeutic effects on the brain. Recent research suggests that psilocybin may contribute to the regrowth of dendritic spines, the tiny protrusions on neurons that facilitate communication between brain cells.


Dendritic spines play a crucial role in synaptic plasticity, which is the ability of synapses to change in strength or form new connections. Dr. David Olson, a neuroscientist at the University of California, Davis, explains, "we grew cortical neurons in the lab and treated them with a wide variety of structurally distinct psychedelic compounds including LSD, DMT, and MDMA. Psychedelic treatment caused these neurons to grow more dendritic branches, dendritic spines, and synapses—the key elements that allow for communication between neurons." Animal studies have demonstrated that these compounds, along with psilocybin promote the formation of new neural connections and enhance cognitive flexibility.


Moreover, early clinical trials indicate the potential of psilocybin in treating mental health conditions such as depression and post-traumatic stress disorder (PTSD). In a landmark study published in JAMA Psychiatry, researchers found that a single dose of psilocybin led to significant reductions in depression and anxiety symptoms in individuals with treatment-resistant depression. In part, the therapeutic effects were attributed to the restoration of neural connectivity and increased neuroplasticity facilitated by psilocybin.


Cold Exposure

Cold exposure, in various forms, has been found to have profound effects on brain function, physical health, and mental well-being. Exposure to cold temperatures activates the body's thermoregulatory system and triggers a cascade of physiological responses that can positively impact the brain.


Cold showers, ice baths, or cryotherapy sessions have been associated with increased alertness, improved mood, enhanced cognitive performance, and reduced symptoms of depression and anxiety. Dr. Rhonda Patrick, a leading expert in nutritional science, explains that "cold exposure stimulates the release of norepinephrine, a neurotransmitter associated with heightened focus and attention. Cold exposure also releases cold shock proteins such as RNA binding motif 3 (RBM3) that is linked to regeneration of synapses."


Additionally, cold exposure promotes the production of brain-derived neurotrophic factor (BDNF), a protein essential for the growth, maintenance, and plasticity of neurons. BDNF plays a crucial role in neurogenesis, the formation of new neurons, and has been linked to improved memory and learning abilities.


Research conducted at the University of Michigan revealed that exposure to cold temperatures can increase the production of BDNF in the hippocampus, a region of the brain critical for learning and memory. The study further demonstrated that cold exposure improved spatial learning and memory in rodents.


Conclusion

Harnessing the potential of neuroplasticity opens up exciting avenues for brain healing and cognitive enhancement. The use of MCT oil as a super fuel for the brain, psilocybin's ability to stimulate dendritic spine growth, and the amazing effects of cold exposure demonstrate the diverse approaches available for promoting brain health and optimizing cognitive performance.


As our understanding of the brain continues to evolve, these interventions provide promising possibilities for individuals seeking to recover from brain-related challenges or enhance their cognitive abilities. However, it is essential to note that further research and clinical studies are warranted to elucidate the full extent of these interventions and their long-term effects on brain health and overall well-being.


Note: This article is for informational purposes only and should not be considered medical advice. Consult with a healthcare professional before implementing any interventions discussed in this article.


Works Cited

1. Arina, Teemu. “Dr. Rhonda Patrick on the Health Benefits of Cold Exposure and Sauna.” Biohacker Summit: World’s Top Biohacking, Health and Wellness Conference, 15 Oct. 2016, biohackersummit.com/2016/10/15/dr-rhonda-patrick-health-benefits-of-sauna/.


2. Carhart-Harris, R. L., Bolstridge, M., Rucker, J., Day, C. M., Erritzoe, D., Kaelen, M., ... & Taylor, D. (2016). Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. JAMA psychiatry, 73(9), 993-1002.


3. Fortier, M., Castellano, C. A., Croteau, E., Langlois, F., Bocti, C., St-Pierre, V., ... & Fulop, T. (2019). A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5, 518-528.


4. Lezi, E., Burns, J. M., & Swerdlow, R. H. (2014). Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiology of aging, 35(11), 2574-2583.


5. Minute, Academic. “David Olson, University of California Davis – Psychedelics as Treatment for Depression.” The Academic Minute, 30 Jan. 2020, academicminute.org/2019/02/david-olson-university-of-california-davis-psychedelics-as-treatment-for-depression/.


6. Modern Healthspan, Richard, director. Combined Benefits Of MCT & Coconut Oil | Dr Mary Newport Interview Series Ep 2. YouTube, Modern Healthspan , 24 Jan. 2023, https://youtu.be/5NK-JUvLW-Y. Accessed 22 June 2023.


7. Olson, D. E. (2018). Psychedelics for the treatment of depression, PTSD, and substance use disorder. Pharmacological reviews, 70(2), 661-663.


8. Teixeira, P. J., Oliveira, M., & Casal, S. (2013). Bioactive lipids: metabolic fluxes and modulation by diet. In Biochemistry of lipids, lipoproteins and membranes (pp. 267-307). Elsevier.


9. Zhang, Y., & Chopp, M. (2009). Exogenous hypoxia-High altitude and hyperbaric oxygen. In Cerebral angiogenesis: Methods and protocols (pp. 221-230). Humana Press.


Key Words: Neuroplasticity, Brain Healing, Cognitive Enhancement, MCT Oil, Ketones, High-Octane Fuel, Psilocybin, Dendritic Spines, Cold Exposure, Cognitive Performance, Mental Health, Brain Function, Neurogenesis, BDNF, Cold Showers, Ice Baths, Cryotherapy, Norepinephrine, Focus, Attention, Memory, Depression, Anxiety, Research, Clinical Studies.

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